The WHO Pediatric ARV dosing dashboard aims to support health care workers, researchers and policy makers in decisions around ARV dosing for children. It includes a dosing tool to assist in selecting the correct dose for infants, children and adolescents less than 18 years of age, background information to support WHO pediatric weight-band dosing recommendations for ARV drugs, and a tool for researchers who may want to investigate various ARV dosages and calculate the expected drug exposure in children relative to adult targets after administration of various doses.
The dosing tool generates an advice for the preferred ARVs combinations, preferred formulation, and recommended dose based on the child’s weight, age, swallowing capability, concomitant use of TB treatment, gestational age (only for neonates), and previous medications used (only for 2nd line treatment). The dose recommendations are based on the WHO pediatric dosing annex and reflect the dosing recommendations of the Pediatric ARV Working Group (PAWG).
With the introduction of harmonized pediatric weight-band dosing for ARVs, some WHO dose recommendations deviate from the manufacturer’s package insert. The background information pages include the scientific rationale and considerations behind the WHO recommended doses in case these deviate from the manufacturer’s package insert. The pages also include information about knowledge gaps, considerations with regards to formulations, frequently occurring drug-drug interactions, and other important information with regards to dosing.
This tool will be periodically updated to reflect new evidence and new dosing recommendations as those become available.