HIV New Product Introduction Toolkit

Clinical Evidence Resources on COVID-19 and HIV

• Therapeutic Options for COVID-19 Currently Under Investigation (NIH, Ongoing)

• A Trial of LPV/r in Adults Hospitalized with Severe COVID-19 (NEJM, March 2020)

• Systematic Review of the efficacy and safety of ARVs against SARS, MERS, of COVID-19 (JIAS, March 2020)

• COVID-19 in Patients with HIV: Clinical Case Series (Lancet, April 2020)

• Darunavir does not prevent SARS CoV-2 infection in HIV patients (Pharmacological Research, April 2020)

• Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomized, phase 2 trial (Lancet, May 2020)

• Potential effects of disruption to HIV programs in sub-Saharan Africa caused by COVID-19: results from multiple models (WHO, May 2020)

• COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients (Journal of Infectious Disease, May 2020)

• Spanish study raises possibility that old-style tenofovir might protect against COVID-19 (aidsmap, June 2020)

• COVID-19, HIV and TB Webinar - COVID-19 and TPT (Arum Institute, June 2020)

• COVID-19, HIV and TB Webinar - Dr. Mary-Ann Davies, Western Cape Department of Health: Preliminary Analysis of Risk Factors for COVID-19 deaths in the province (Arum Institute, June 2020)

• London study shows people with HIV not at greater risk of severe COVID-19 illness (aidsmap, July 2020)

• COVID-19 affects HIV and tuberculosis care (AAAS Science, July 2020)

• No link between HIV status and coronavirus outcomes in large US study (aidsmap, July 2020)

• Two UK studies find that HIV infection may be a risk factor for dying from COVID-19 (aidsmap, August 2020)

• High prevalence of underlying health conditions explains increased COVID-19 mortality seen in people with HIV in US study (aidsmap, September 2020)

• COVID-19 more prevalent among general vs HIV-positive population, Barcelona study says (AJMC, September 2020)

• Preventive efficacy of tenofovir/emtricitabine against SARS-CoV-2 among PrEP users (Oxford Academy, September 2020)

• Characteristics, comorbidities and outcomes in a multicenter registry of patients with HIV and Coronavirus Disease-19 (Oxford Academy, September 2020)

• US study of HIV-positive people with COVID-19 reports worse outcomes with comorbidities and having a CD4 <200 (i-base, October 2020)